Bio-Silica

 

Basic Patent

Describes the mode of action of a first enzyme that catalyzes the formation of an inorganic polymer from inorganic precursors. With the example of silicatein it is demonstrated that bio-silica is a natural inorganic polymer that is synthesized from ortho-silicate through enzymatically driven biocondensation.

 Example:

- Silicatein-mediated synthesis of amorphous silicates and siloxanes and use thereof

- Enzymatic synthesis, modification and degradation of silicon(IV)- and other metal(IV)-compounds

 

Applied Patent

The versatile application of the enzyme, e.g. for the fabrication of nanowires, tooth implants, components of bone implant materials.

 Example:

- Enzymatic Method for Producing Bioactive, Osteoblast Stimulating Surfaces and Use Thereof

- Injectabel Material and material to be used as drug or food supplement for prophylaxis or treatment of osteoporosis

- Osteogenic material to be used for treatment of bone defects

 

Bio-Polyphosphate

Polyphosphate is a natural, inorganic polymer that is synthesized enzymatically in cells, surrounding bone defects. We demonstrated that this polymer elicit morphogenetic activity, especially on bone cells.

 Example:

- Modulator of bone mineralization based on a combination of polyphosphate/carbonate and carbonic anhydrase activators

- Synergistic composition comprising quercetin and polyphosphate for treatment of bone disorders

 

Basic Patent

Application of polyphosphate in implants that induces regeneration in damaged bone tissue.

 Example:

- Food supplement and injectable material for prophylaxis and therapy of osteoporosis and other bone diseases

 

Bio-Calcite

Use of amorphous bio-calcite as an essential component for the initiation of bone hydroxyapatite formation.

Example:

- Morphogenetically active calcium polyphosphate nanoparticles

 

Bio-Glass

Description of a novel composition of an osteoinductive bio-glass as a component of a biomaterial that can be printed to customized implants.

 Example:

- 3D cell printing of bioglass containing scaffolds by combination with cell-containing morphogenically active alginate/gelatine hydrogels

 

Bio-Printing

Application of novel biomaterials for implants, fabricated in a personalized manner.

 Example:

- Morphogenetically active hydrogel for bioprinting of bioartificial tissue