Describes the mode of action of a first enzyme that catalyzes the formation of an inorganic polymer from inorganic precursors. With the example of silicatein it is demonstrated that bio-silica is a natural inorganic polymer that is synthesized from ortho-silicate through enzymatically driven biocondensation.
- Silicatein-mediated synthesis of amorphous silicates and siloxanes and use thereof
- Enzymatic synthesis, modification and degradation of silicon(IV)- and other metal(IV)-compounds
The versatile application of the enzyme, e.g. for the fabrication of nanowires, tooth implants, components of bone implant materials.
- Enzymatic Method for Producing Bioactive, Osteoblast Stimulating Surfaces and Use Thereof
- Injectabel Material and material to be used as drug or food supplement for prophylaxis or treatment of osteoporosis
- Osteogenic material to be used for treatment of bone defects
Polyphosphate is a natural, inorganic polymer that is synthesized enzymatically in cells, surrounding bone defects. We demonstrated that this polymer elicit morphogenetic activity, especially on bone cells.
- Modulator of bone mineralization based on a combination of polyphosphate/carbonate and carbonic anhydrase activators
- Synergistic composition comprising quercetin and polyphosphate for treatment of bone disorders
Application of polyphosphate in implants that induces regeneration in damaged bone tissue.
- Food supplement and injectable material for prophylaxis and therapy of osteoporosis and other bone diseases
Use of amorphous bio-calcite as an essential component for the initiation of bone hydroxyapatite formation.
- Morphogenetically active calcium polyphosphate nanoparticles
Description of a novel composition of an osteoinductive bio-glass as a component of a biomaterial that can be printed to customized implants.
- 3D cell printing of bioglass containing scaffolds by combination with cell-containing morphogenically active alginate/gelatine hydrogels
Application of novel biomaterials for implants, fabricated in a personalized manner.
- Morphogenetically active hydrogel for bioprinting of bioartificial tissue